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Aims of the study is to evaluate the cytokine profile and innate immunity parameters in laparoscopic (LLR) and open resections (OLR) of liver metastases. Methods. 30 patients with liver metastases were operated on in the volume (LLR) 14 patients and (OLR) 16 patients, the control group was 10 practically healthy test persons. Blood samples was carried out before the operation, after 6 hours, 24 hours and on the 7th day. The coefficient balance of Th 1/2, 1/9, 1/17, 1/22 and Th 2/9, 2/17, 2/22 was assessed by their cytokine profiles IL-1b, IL-2, IL-4, IL- 5, IL-6, IL-10, IL 17a, IL 22, IL 9. Statistical analysis was performed using the program Statistica 10. Statistical significance was determined by non-parametric Kruskal-Wallis test with Dunn's posterior test. Results. In patients with cancer, cytokine levels are initially elevated before surgery compared with the control group. Open liver resections were characterized by a greater increase in the level of cytokines characteristic of Th9/Th17/Th22 helper cell subpopulations compared with laparoscopic operations and the control group. Conclusion. When performing laparoscopic operations, the imbalance of the cytokine system of helper cells is significantly lower than with open resections.