Reduced neural activity during volatile compared to total intravenous anesthesia: evidence from a novel EEG signal processing analysis
EAES Academy. Bickel a. 07/05/22; 363111; P156
amitai Bickel
Contributions
Contributions
Abstract
Background:
Post-operative cognitive decline is a well-known phenomenon and of crucial importance especially in the elderly, emphasizing the importance of selecting the proper anesthesia. General anesthesia can be accomplished by volatile or total intravenous (TIVA) anesthesia. Currently little is known about their influence on brain functionalities during surgery.
Aims: To assess differences in brain activity between volatile and TIVA anesthetics during surgery.
Methods:
Patients who were electively scheduled for laparoscopic cholecystectomy gave informed consent to participate in the study, and were randomly divided to receive either volatile anesthesia (n=9) or TIVA (n=8). The level of anesthesia was kept to be equal in both groups. A single bipolar EEG electrode (Aurora by Neurosteer) was placed on the participants' foreheads. It presented real-time activity and collected their data during surgery. The dependent variables included frequency bands (delta, theta, alpha and beta), and three biomarkers that were previously extracted with the Aurora device and provided by Neurosteer.
Results:
All surgeries were uneventful, and all patients showed bispectral index (BIS) less than 60. Biomarker activity under volatile anesthesia (in compare to TIVA) was significantly lower for the theta, delta and alpha frequency bands and for the three biomarkers (VC9, ST4, and A0). Further analysis showed that the largest difference between anesthesia types was for biomarker A0.
Conclusions:
Both EEG frequency bands and novel brain activity biomarkers provide evidence that volatile anesthesia further reduces components of brain activity in comparison to TIVA anesthesia. Specifically, A0 , which previously showed a correlation with cognitive decline severity and cognitive load, exhibited the most prominent difference between anesthesia types. Together, this study suggests that measuring brain activity during anesthesia using sensitive biomarkers, enables revealing that different anesthesia types may affect brain activity differently, which could affect the recovery from anesthesia, and consequently reduce post-operative cognitive decline.
Post-operative cognitive decline is a well-known phenomenon and of crucial importance especially in the elderly, emphasizing the importance of selecting the proper anesthesia. General anesthesia can be accomplished by volatile or total intravenous (TIVA) anesthesia. Currently little is known about their influence on brain functionalities during surgery.
Aims: To assess differences in brain activity between volatile and TIVA anesthetics during surgery.
Methods:
Patients who were electively scheduled for laparoscopic cholecystectomy gave informed consent to participate in the study, and were randomly divided to receive either volatile anesthesia (n=9) or TIVA (n=8). The level of anesthesia was kept to be equal in both groups. A single bipolar EEG electrode (Aurora by Neurosteer) was placed on the participants' foreheads. It presented real-time activity and collected their data during surgery. The dependent variables included frequency bands (delta, theta, alpha and beta), and three biomarkers that were previously extracted with the Aurora device and provided by Neurosteer.
Results:
All surgeries were uneventful, and all patients showed bispectral index (BIS) less than 60. Biomarker activity under volatile anesthesia (in compare to TIVA) was significantly lower for the theta, delta and alpha frequency bands and for the three biomarkers (VC9, ST4, and A0). Further analysis showed that the largest difference between anesthesia types was for biomarker A0.
Conclusions:
Both EEG frequency bands and novel brain activity biomarkers provide evidence that volatile anesthesia further reduces components of brain activity in comparison to TIVA anesthesia. Specifically, A0 , which previously showed a correlation with cognitive decline severity and cognitive load, exhibited the most prominent difference between anesthesia types. Together, this study suggests that measuring brain activity during anesthesia using sensitive biomarkers, enables revealing that different anesthesia types may affect brain activity differently, which could affect the recovery from anesthesia, and consequently reduce post-operative cognitive decline.
Background:
Post-operative cognitive decline is a well-known phenomenon and of crucial importance especially in the elderly, emphasizing the importance of selecting the proper anesthesia. General anesthesia can be accomplished by volatile or total intravenous (TIVA) anesthesia. Currently little is known about their influence on brain functionalities during surgery.
Aims: To assess differences in brain activity between volatile and TIVA anesthetics during surgery.
Methods:
Patients who were electively scheduled for laparoscopic cholecystectomy gave informed consent to participate in the study, and were randomly divided to receive either volatile anesthesia (n=9) or TIVA (n=8). The level of anesthesia was kept to be equal in both groups. A single bipolar EEG electrode (Aurora by Neurosteer) was placed on the participants' foreheads. It presented real-time activity and collected their data during surgery. The dependent variables included frequency bands (delta, theta, alpha and beta), and three biomarkers that were previously extracted with the Aurora device and provided by Neurosteer.
Results:
All surgeries were uneventful, and all patients showed bispectral index (BIS) less than 60. Biomarker activity under volatile anesthesia (in compare to TIVA) was significantly lower for the theta, delta and alpha frequency bands and for the three biomarkers (VC9, ST4, and A0). Further analysis showed that the largest difference between anesthesia types was for biomarker A0.
Conclusions:
Both EEG frequency bands and novel brain activity biomarkers provide evidence that volatile anesthesia further reduces components of brain activity in comparison to TIVA anesthesia. Specifically, A0 , which previously showed a correlation with cognitive decline severity and cognitive load, exhibited the most prominent difference between anesthesia types. Together, this study suggests that measuring brain activity during anesthesia using sensitive biomarkers, enables revealing that different anesthesia types may affect brain activity differently, which could affect the recovery from anesthesia, and consequently reduce post-operative cognitive decline.
Post-operative cognitive decline is a well-known phenomenon and of crucial importance especially in the elderly, emphasizing the importance of selecting the proper anesthesia. General anesthesia can be accomplished by volatile or total intravenous (TIVA) anesthesia. Currently little is known about their influence on brain functionalities during surgery.
Aims: To assess differences in brain activity between volatile and TIVA anesthetics during surgery.
Methods:
Patients who were electively scheduled for laparoscopic cholecystectomy gave informed consent to participate in the study, and were randomly divided to receive either volatile anesthesia (n=9) or TIVA (n=8). The level of anesthesia was kept to be equal in both groups. A single bipolar EEG electrode (Aurora by Neurosteer) was placed on the participants' foreheads. It presented real-time activity and collected their data during surgery. The dependent variables included frequency bands (delta, theta, alpha and beta), and three biomarkers that were previously extracted with the Aurora device and provided by Neurosteer.
Results:
All surgeries were uneventful, and all patients showed bispectral index (BIS) less than 60. Biomarker activity under volatile anesthesia (in compare to TIVA) was significantly lower for the theta, delta and alpha frequency bands and for the three biomarkers (VC9, ST4, and A0). Further analysis showed that the largest difference between anesthesia types was for biomarker A0.
Conclusions:
Both EEG frequency bands and novel brain activity biomarkers provide evidence that volatile anesthesia further reduces components of brain activity in comparison to TIVA anesthesia. Specifically, A0 , which previously showed a correlation with cognitive decline severity and cognitive load, exhibited the most prominent difference between anesthesia types. Together, this study suggests that measuring brain activity during anesthesia using sensitive biomarkers, enables revealing that different anesthesia types may affect brain activity differently, which could affect the recovery from anesthesia, and consequently reduce post-operative cognitive decline.
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