Multimodal prehabilitation to improve postoperative outcomes after high impact surgery – study protocol of the F4S PREHAB trial
EAES Academy. Strijker D. 07/05/22; 363113; P158
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Abstract
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Background:
High impact surgery for oncological diseases is associated with postoperative complications occurring in up to 60% of patients, leading into higher mortality rates, prolonged hospital stays and impaired quality of life (QoL). Prehabilitation, a process to optimize a patient’s preoperative functional capacity (figure 1), has led to a 35-51% reduction of complications after colorectal surgery. Therefore, prehabilitation promises to be an effective intervention to improve postoperative outcomes in various types of oncological surgery.
Methods:
A stepped-wedge cluster randomized trial (figure 2) will be performed to demonstrate the effects of a multimodal prehabilitation program (exercise program, nutritional intervention, psychological support and smoking cessation support) on clinical outcomes across a wide range of oncological patients, diseases and procedures (open and endoscopic) (n=2828).
Discussion:
Multimodal prehabilitation is expected to reduce postoperative complications and length of stay. It may therefore result in lower mortality rates, improved QoL and reduced hospital costs.
Trial registration: Netherlands Trial Register: NL8699 – date of registration: 5 June 2020
High impact surgery for oncological diseases is associated with postoperative complications occurring in up to 60% of patients, leading into higher mortality rates, prolonged hospital stays and impaired quality of life (QoL). Prehabilitation, a process to optimize a patient’s preoperative functional capacity (figure 1), has led to a 35-51% reduction of complications after colorectal surgery. Therefore, prehabilitation promises to be an effective intervention to improve postoperative outcomes in various types of oncological surgery.
Methods:
A stepped-wedge cluster randomized trial (figure 2) will be performed to demonstrate the effects of a multimodal prehabilitation program (exercise program, nutritional intervention, psychological support and smoking cessation support) on clinical outcomes across a wide range of oncological patients, diseases and procedures (open and endoscopic) (n=2828).
Discussion:
Multimodal prehabilitation is expected to reduce postoperative complications and length of stay. It may therefore result in lower mortality rates, improved QoL and reduced hospital costs.
Trial registration: Netherlands Trial Register: NL8699 – date of registration: 5 June 2020
Background:
High impact surgery for oncological diseases is associated with postoperative complications occurring in up to 60% of patients, leading into higher mortality rates, prolonged hospital stays and impaired quality of life (QoL). Prehabilitation, a process to optimize a patient’s preoperative functional capacity (figure 1), has led to a 35-51% reduction of complications after colorectal surgery. Therefore, prehabilitation promises to be an effective intervention to improve postoperative outcomes in various types of oncological surgery.
Methods:
A stepped-wedge cluster randomized trial (figure 2) will be performed to demonstrate the effects of a multimodal prehabilitation program (exercise program, nutritional intervention, psychological support and smoking cessation support) on clinical outcomes across a wide range of oncological patients, diseases and procedures (open and endoscopic) (n=2828).
Discussion:
Multimodal prehabilitation is expected to reduce postoperative complications and length of stay. It may therefore result in lower mortality rates, improved QoL and reduced hospital costs.
Trial registration: Netherlands Trial Register: NL8699 – date of registration: 5 June 2020
High impact surgery for oncological diseases is associated with postoperative complications occurring in up to 60% of patients, leading into higher mortality rates, prolonged hospital stays and impaired quality of life (QoL). Prehabilitation, a process to optimize a patient’s preoperative functional capacity (figure 1), has led to a 35-51% reduction of complications after colorectal surgery. Therefore, prehabilitation promises to be an effective intervention to improve postoperative outcomes in various types of oncological surgery.
Methods:
A stepped-wedge cluster randomized trial (figure 2) will be performed to demonstrate the effects of a multimodal prehabilitation program (exercise program, nutritional intervention, psychological support and smoking cessation support) on clinical outcomes across a wide range of oncological patients, diseases and procedures (open and endoscopic) (n=2828).
Discussion:
Multimodal prehabilitation is expected to reduce postoperative complications and length of stay. It may therefore result in lower mortality rates, improved QoL and reduced hospital costs.
Trial registration: Netherlands Trial Register: NL8699 – date of registration: 5 June 2020
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