Tumor Budding Is a Risk Factor of Lymph Node Move in Early Gastric Cancer: A Retrospective Research
EAES Academy. Ji X. 07/05/22; 366525; P242
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Abstract
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Aims: To elucidate the correlation between tumor budding grade and clinicopathological characteristics in patients with early gastric cancer and determine whether it can be used as an independent predictor of lymph node metastasis in early gastric cancer, guiding whether the additional gastrectomy with lymphadenectomy is necessary after the endoscopic resection.
Methods: we evaluated 124 cases of EGC with pathological confirmation of T1a/T1b stage after the lymphadenectomy in our center from 2017 to 2020 . Clinical data included gender, age, BMI, tumor site, Lauren, histologic type, T1a/T1b, LNM, en. Postoperative pathological specimens were evaluated using H&E staining and immunohistochemical staining (E-cadherin, CK7 maker). Two experienced pathologists assessed TB scores according to the Ueno “hot spot” method.
Results: Lymph node metastasis in EGC was significantly correlated with TB grade, tumor site, Lauren's staging, histologic type, T stage, and CK7 expression. In the ROC curve fitted by binary logistic regression analysis, TB had the most significant area under the curve, while TB was only correlated with T stage and BMI. LNM and TB were both not significantly associated with gender and age，while a significant statistical relationship was found between TB and LNM when adjusting for gender(male) or age(>60) .
Conclusions: High tumor budding is a risk factor for lymph node metastasis in early gastric cancer and may predict the possibility of continued tumor infiltration. Lymph node dissection based on radical resection of the primary site is necessary for patients with high TB, especially those with T1b stage, Lauren's grading of non-intestinal type, and intermediate - low differentiation.
Methods: we evaluated 124 cases of EGC with pathological confirmation of T1a/T1b stage after the lymphadenectomy in our center from 2017 to 2020 . Clinical data included gender, age, BMI, tumor site, Lauren, histologic type, T1a/T1b, LNM, en. Postoperative pathological specimens were evaluated using H&E staining and immunohistochemical staining (E-cadherin, CK7 maker). Two experienced pathologists assessed TB scores according to the Ueno “hot spot” method.
Results: Lymph node metastasis in EGC was significantly correlated with TB grade, tumor site, Lauren's staging, histologic type, T stage, and CK7 expression. In the ROC curve fitted by binary logistic regression analysis, TB had the most significant area under the curve, while TB was only correlated with T stage and BMI. LNM and TB were both not significantly associated with gender and age，while a significant statistical relationship was found between TB and LNM when adjusting for gender(male) or age(>60) .
Conclusions: High tumor budding is a risk factor for lymph node metastasis in early gastric cancer and may predict the possibility of continued tumor infiltration. Lymph node dissection based on radical resection of the primary site is necessary for patients with high TB, especially those with T1b stage, Lauren's grading of non-intestinal type, and intermediate - low differentiation.
Aims: To elucidate the correlation between tumor budding grade and clinicopathological characteristics in patients with early gastric cancer and determine whether it can be used as an independent predictor of lymph node metastasis in early gastric cancer, guiding whether the additional gastrectomy with lymphadenectomy is necessary after the endoscopic resection.
Methods: we evaluated 124 cases of EGC with pathological confirmation of T1a/T1b stage after the lymphadenectomy in our center from 2017 to 2020 . Clinical data included gender, age, BMI, tumor site, Lauren, histologic type, T1a/T1b, LNM, en. Postoperative pathological specimens were evaluated using H&E staining and immunohistochemical staining (E-cadherin, CK7 maker). Two experienced pathologists assessed TB scores according to the Ueno “hot spot” method.
Results: Lymph node metastasis in EGC was significantly correlated with TB grade, tumor site, Lauren's staging, histologic type, T stage, and CK7 expression. In the ROC curve fitted by binary logistic regression analysis, TB had the most significant area under the curve, while TB was only correlated with T stage and BMI. LNM and TB were both not significantly associated with gender and age，while a significant statistical relationship was found between TB and LNM when adjusting for gender(male) or age(>60) .
Conclusions: High tumor budding is a risk factor for lymph node metastasis in early gastric cancer and may predict the possibility of continued tumor infiltration. Lymph node dissection based on radical resection of the primary site is necessary for patients with high TB, especially those with T1b stage, Lauren's grading of non-intestinal type, and intermediate - low differentiation.
Methods: we evaluated 124 cases of EGC with pathological confirmation of T1a/T1b stage after the lymphadenectomy in our center from 2017 to 2020 . Clinical data included gender, age, BMI, tumor site, Lauren, histologic type, T1a/T1b, LNM, en. Postoperative pathological specimens were evaluated using H&E staining and immunohistochemical staining (E-cadherin, CK7 maker). Two experienced pathologists assessed TB scores according to the Ueno “hot spot” method.
Results: Lymph node metastasis in EGC was significantly correlated with TB grade, tumor site, Lauren's staging, histologic type, T stage, and CK7 expression. In the ROC curve fitted by binary logistic regression analysis, TB had the most significant area under the curve, while TB was only correlated with T stage and BMI. LNM and TB were both not significantly associated with gender and age，while a significant statistical relationship was found between TB and LNM when adjusting for gender(male) or age(>60) .
Conclusions: High tumor budding is a risk factor for lymph node metastasis in early gastric cancer and may predict the possibility of continued tumor infiltration. Lymph node dissection based on radical resection of the primary site is necessary for patients with high TB, especially those with T1b stage, Lauren's grading of non-intestinal type, and intermediate - low differentiation.
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